For nearly two decades now, KMTNC has successfully under taken over 100 small and large projects on nature conservation, biodiversity protection, natural resource management and sustainable rural development programs. The Trust's experience over the years has shown that the conservation efforts in poor and over populated country, such as Nepal, cannot be successful, much less sustainable, unless it addresses the needs and welfare of the local people. Holistic and integrated conservation and development program with active people participation aimed at promoting local guardianship, thus, have been the focus of all KMTNC's activities.

Geographically, the Trust's activities have spread from the tropical plains of Chitwan and Bardia in the lowland to the Annapurna and Manaslu regions of the high Himalayas, including the Trans Himalayan regions of Upper Mustang and Manang. Currently projects of the Trust are divided into three geographical areas - the Terai Environment Program focusing on the lowland, the Mountain Environment Program focusing on the mid hills and high mountains, and the Kathmandu Valley. The Trust's activities in the lowland are based in and around the Royal Chitwan National Park (RCNP) and the Royal Bardia National Park (RBNP) located in the central and western regions of Nepal, respectively. Similarly, the Annapurna Conservation Area Project (ACAP) and the Manaslu Conservation Area Project (MCAP) are two major projects in the mountain environment. The management of the Central Zoo is the only project of the Trust in the Kathmandu Valley. Currently, there are about 500 staff working for the Trust. Similarly, in total over 400,000 people, and 200,000 tourists and their support crews have been benefited every year from KMTNC's endeavors.